Alzheimer's Research

We report a case of familial dementia having some clinical features characteristic of dementia with Lewy bodies, in which a novel mutation Ala275Ser within the presenilin-1 (PSEN1) gene was identified. We review the association...

Mendelian randomization analysisWe used two-sample Mendelian randomization4 to examine (i) whether APOE4 (tagged by the C allele of single nucleotide polymorphism rs4293585) has a causal effect on blood-based CypA or MMP9 expression quantitative trait...

1.Prince, M., Guerchet, M. & Prina, M. The Global Impact of Dementia 2013–2050 Policy Brief for Heads of Government. https://www.alz.co.uk/research/GlobalImpactDementia2013 (2013).2.Nichols, E. et al. Global, regional, and national burden of Alzheimer’s disease and other...

Western blot analysis and chemicalsWestern blotting was performed as described previously32. Mouse tissue and cells were lysed in RIPA with Roche cOmplete™ mini tablets (Roche, Mannheim, Germany), 25 µM MG132 (EMD Chemicals, Inc; San...

Introduction: Although exercise is associated with a lower risk for mild cognitive impairment (MCI), it is unclear whether its protective effect depends on the presence or absence of vascular factors. Methods: In an exploratory study...

The UC San Francisco Department of Radiology and Biomedical Imaging is pleased to announce that Jesse Courtier, MD has accepted the position of chief, UCSF Benioff Children's Hospitals in San Francisco Pediatric...

Objectives: The current study addresses the nature of memory difficulties in amnestic mild cognitive impairment (aMCI). Whereas recollection is consistently found to be impaired in aMCI, the results on familiarity are divergent. One potential...

Get a comprehensive state-of-the-art update on clinically relevant topics in neuroradiology and musculoskeletal imaging set against a beautiful backdrop - the Fairmont Orchid on the Big Island of Hawaii. Join...

We create countless memories as we live our lives but many of these we forget. Why? Counter to the general assumption that memories simply decay with time, 'forgetting' might not be a bad thing...

Both clinical radiologists who specialize in breast imaging and radiologists who have general diagnostic clinical duties are invited to attend the Breast Imaging Update at the Fairmont Orchid on the...