TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities
Cell cultures and animalsHEK293T, Hela, and BV2 cells were originally from ATCC (Manassas, VA, USA) and maintained in our laboratory. These cells and mouse primary microglial cells were prepared and cultured as previously described19,42,57,58....
Police Interactions Among Neuropathologically Confirmed Dementia Patients: Prevalence and Cause
Objective:
The aim of this study was to investigate and compare the prevalence and recurrence of police interaction (PI) with patients diagnosed with dementia. We also aimed to study the reason behind the PI,...
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Get a State-of-the-Art Update on Neuroradiology and Musculoskeletal Imaging with UCSF Radiology CME
Get a comprehensive state-of-the-art update on clinically relevant topics in neuroradiology and musculoskeletal imaging set against a beautiful backdrop - the Fairmont Orchid on the Big Island of Hawaii. Join...
Cannabinoid receptor type 2 agonist JWH-133 decreases cathepsin B secretion and neurotoxicity from HIV-infected...
Cell culture, HIV-1ADA infection, and treatmentsPeripheral blood mononuclear cells (PBMCs) were isolated from healthy women blood donors as part of the NIH/NIGMS SC1 project: “Targeting monocyte/macrophage cathepsin B interactome in HIV-1 neurocognitive disorders”, with...
Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE...
Schneider, J. A., Arvanitakis, Z., Bang, W. & Bennett, D. A. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69, 2197–2204 (2007).PubMed
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Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain...
Preclinical study designMouse experimentation and animal care were approved by the Institutional Animal Care and Use Committee (IACUC) of the Nathan S. Kline Institute. Ts2 (Stock No. 004850) mice, and wild type breeding partner...
‘Happy hormone’ dopamine plays role in identifying emotions — ScienceDaily
Emotion-recognition among people with disorders such as Parkinson's disease or schizophrenia may be affected by changes in the levels dopamine in the brain, say researchers at the University of Birmingham.
Dopamine is a chemical messenger...
The cognitive and psychiatric subacute impairment in severe Covid-19
Li, Q. et al. Early Transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. N. Engl. J. Med. 382, 1199–1207 (2020).CAS
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Examining Leukemia Risks Among Children with Down Syndrome
Down syndrome is one of the most common genetic conditions in the U.S. and Canada. According to the Centers for Disease Control and Prevention (CDC), about 6,000 babies with Down...
A small molecule blocks aversive memory formation, providing a potential treatment target for depression
Depression is one of the most common mental illnesses in the world, but current anti-depressants have yet to meet the needs of many patients. Neuroscientists from City University of Hong Kong (CityU) recently discovered...
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...