Hypothesis: cerebrospinal fluid protein markers suggest a pathway toward symptomatic resilience to AD pathology
Jump to Section1. Introduction2. Methods 2.1. Participants 2.2. CSF measurements and classification 2.3. APOE genotyping 2.4. Analytic methods 2.4.1. Training and validation sets 2.4.2. LASSO regression modeling of baseline cognitive performance 2.4.3. Applying model weights to predict clinical diagnostic category 2.4.4. Using...
Marcia Gay Harden Honored at Hope on the Horizon Women’s Luncheon in Palm Beach
The Alzheimer's Drug Discovery Foundation (ADDF) honored actress, author, and advocate Marcia Gay Harden at its Hope on the Horizon Luncheon held at The Colony in Palm Beach...
β-amyloid pathology and hippocampal atrophy are independently associated with memory function in cognitively healthy...
1.Hardy, J. & Selkoe, D. J. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 297, 353–356, https://doi.org/10.1126/science.1072994 (2002).2.Rowe, C. C. et al. Amyloid imaging results from the...
Aged-Based Breast Cancer Screening Has A Greater Mortality Benefit Than Risk-Based Breast Cancer Screening
Risk-based factors for risk-based breast cancer screening including family history, race, age, prior breast biopsy, and breast density have not been evaluated in routine screening mammography practice. "Growing interest in...
The Unbroken Circle | Fisher Center for Alzheimer’s Research Foundation
Posted on July 26, 2017 by Tom and Karen Brenner
The Unbroken Circle
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The ADDF Announces New Research Initiative to Advance Digital Tools for Detection for Alzheimer’s
As part of its Diagnostics Accelerator research program, the Alzheimer's Drug Discovery Foundation (ADDF) announced today a new initiative that aims to fast-track the development of digital tools...
Regional mitochondrial DNA and cell-type changes in post-mortem brains of non-diabetic Alzheimer’s disease are...
The aims, design and setting of the studyThe aim of this cross-sectional lab-based study was to quantify mtDNA in specific regions of post-mortem human brain and to determine if diabetes and AD, separately or...
Scientists at UCSF Study Impact of 68Ga-PSMA-11 PET on Post Radical Prostatectomy (RP) Salvage...
Besides skin cancer, prostate cancer is the most common cancer in American men, according to the American Cancer Society. Recurrences of prostate cancer after a patient undergoes radical prostatectomy (RP),...
Clinicopathologic subtype of Alzheimer’s disease presenting as corticobasal syndrome
Fig. 2Macroscopic examples of AD-CBS and AD-AS; comparison of representative cases of AD-CBS (A, B, C) and AD-AS (D, E, F). The midsagittal view shows marked medial frontal atrophy, especially in paracentral lobule and perirolandic...
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...