This study was approved by the appropriate institutional ethics committees at the Douglas Mental Health University Institute Research Ethics Board, Montreal Neurological Instituted PET working committee, Partners HealthCare Institutional Review Board, and Massachusetts General Hospital Radioactive Drug Research Committee, and written informed consent was obtained from the participants. All rat work followed the National Institutes of Health guidelines and was approved by the McGill Animal Care Ethics Committee.
Human participants
We studied 94 participants aged 18–91 years from the community or outpatients at the McGill University Research Centre for Studies in Aging (MCSA, n = 48) and Massachusetts General Hospital (MGH, n = 46). Participants received financial compensation for their time. To ensure external validity, both sites conducted concomitant but entirely independent…
