Instability of brain activity during sleep and anesthesia underlies the pathobiology of Alzheimer’s disease

brain activity
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A new study at Tel Aviv University revealed a pathological brain activity that precedes the onset of Alzheimer’s first symptoms by many years: increased activity in the hippocampus during anesthesia and sleep, resulting from failure in the mechanism that stabilizes the neural network. The researchers believe that the discovery of this abnormal activity during specific brain states may enable early diagnosis of Alzheimer’s, eventually leading to a more effective treatment of a disease that still lacks effective therapies.

The study was led by Prof. Inna Slutsky and doctoral students Daniel Zarhin and Refaela Atsmon from the Sackler…

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