Transcranial ultrasound used in mice with Alzheimer’s disease features

By
dementianews
-
Transcranial ultrasound used in mice with Alzheimer's disease features
Experiment protocol. (a) EEG electrode positions for surgical implantation. E1 and E2 indicate electrodes on the frontal and parietal cortex, respectively, while reference electrode (R) was placed on cerebellum. G and A correspond to the electrodes for animal grounding and the anchoring screw, respectively. Red dots denote the location of implants for EEG signal generation; black dots represent implants generating no signal. (b) tUS and EEG recording device setup. A piezo-ceramic transducer (PZT) with two connecting wires was placed on top of the head-mount layer, which included an EEG electrode and was attached with dental cement. (c) Ultrasound parameter protocol. A 3-ms ultrasound pulse train at 300 kHz was followed by a 22-ms intervening period to make a carrier frequency of 40 Hz. A 10-s stimulation block…

Read more…

RELATED ARTICLESMORE FROM AUTHOR