Scientists identify malfunctioning brain cells as potential target for Alzheimer’s treatment

Scientists identify malfunctioning brain cells as potential target for Alzheimer's treatment
In Orr’s lab, human brain tissues are labeled with fluorescent markers to visualize all cells (turquoise). The rare senescent cell population can be identified by using additional markers to visualize CDKN2D/p19 (white spots) and tau tangles (red). Credit: Wake Forest School of Medicine

For the first time, scientists have identified a rare population of potentially toxic senescent cells in human brains that can serve as a target for a new Alzheimer’s disease treatment.

The study, published in the Dec.10 edition of the journal Nature Aging, was led by Miranda Orr, Ph.D., assistant professor of gerontology and geriatric medicine, at Wake Forest School of Medicine…

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