Does Estrogen Protect Against the Risk of Brain Shrinkage?

Newswise — MINNEAPOLIS – A new study found that people with higher cumulative estrogen exposure over their lifetime had greater brain volumes and fewer indicators of brain disease on their brain scans in midlife . The research is published in the November 3, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology.

“We found that a number of ways a woman is exposed to estrogen—not having reached menopause, having more total reproductive years, having a higher number of children, using menopause hormone therapy or hormonal contraceptives—were associated with larger gray matter volumes in midlife,” said  author Lisa Mosconi, PhD, of Weill Cornell Medicine in New York, N.Y.

The study looked at 99 women between the ages of 40 and 65 who did not have dementia. They did have risk factors for late-onset Alzheimer’s, such as family history of…

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