Protein from the liver may cause Alzheimer’s disease in the brain

Protein from the liver may cause Alzheimer’s disease in the brain
Hippocampal dentate gyrus in HSHA mice, showing significant astrocyte activation (GFAP: white) and oxidative stress (8OHdG: green) surrounding the cerebral capillaries (laminin-a4: magenta). Nuclei staining with DAPI (blue). Credit: John Charles Louis Mamo, Lam V et al., 2021, PLOS Biology, CC BY 4.0 (creativecommons.org/licenses/by/4.0/)

Amyloid protein made in the liver can cause neurodegeneration in the brain, according to a new study in the open-access journal PLOS Biology, by John Mamo of Curtin University in Bentley, Australia, and colleagues. Since the protein is thought to be a key contributor to development of Alzheimer’s disease (AD), the results suggest that the liver may play an important role in the onset or progression of the disease.

Read more…