Stem cells model genetic risk for developing Alzheimer’s disease

Stem cells model genetic risk for developing Alzheimer’s disease
Cholesterol oversupply from ApoE4 astrocytes promote Aβ production in neurons. Credit: Jinsoo Seo

New research published in Stem Cell Reports has found elevated cholesterol supply from astrocytes to neurons in the model of Alzheimer’s disease (AD) brains, suggesting that modulating brain cholesterol could be explored in the search of treatment options for the devastating, degenerative disease.

AD, the most frequent cause of dementia, affects an estimated 24 million people worldwide. With very limited treatment options, scientists are looking for ways to understand the disease better. One hallmark of AD is the emergence of so-called , clumps…

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