Alzheimer’s disease may start inside nerve cells

By
dementianews
-
Alzheimer's disease may start inside nerve cells
Prion-like cell lysate seeds plaques in vivo. a Timeline of unilateral injections into hippocampus of 7-week-old 5xFAD mice, followed by labeling at 23 weeks with MOAB2 (Aβ, green) and NeuN (neuronal cell bodies, magenta). b Unilateral injection in hippocampus of 5xFAD transgenic mouse with lysate of APPSwe N2a cells. Plaque quantification of the upper parts of the dentate molecular layer, and CA1 stratum lacunosum-moleculare and stratum radiatum (paired t test with Bonferroni correction, p = 0.18, df = 2, mean difference = 0.14 and SD of mean difference = 0.076, dashed lines indicate paired data and n = 3). c Mouse injected with cell lysate of prion-like cells. The induced plaques are found adjacent to the hippocampal fissure (arrow). Plaque quantification paired t test with Bonferroni…

Read more…

RELATED ARTICLESMORE FROM AUTHOR