Curcumin for amyloidosis and lipid metabolism—a novel insight

Curcumin for amyloidosis and lipid metabolism -- a novel insight
Schematic diagram of the effect of curcumin mediated by PPARa pathway in AApoAII amyloidosis model mouse. Credit: Jian Dai

Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, which include anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties. However, the mechanism and network of action are not completely clear. Amyloidosis is a group of diseases characterized by abnormal aggregates of proteins, known as amyloid fibrils, and subsequent deposition in various tissues and organs, such as Alzheimer’s disease, immunoglobulin light chain amyloidosis.

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