Genetics study finds ancestral background can affect Alzheimer’s disease risk

Genetics study finds ancestral background can affect Alzheimer's disease risk
The difference in APOE expression between African and European local ancestry carriers. University of Miami Leonard M. Miller School of Medicine

Genetics contributes to the risk of developing Alzheimer’s disease, and the APOE gene is the strongest genetic risk factor, specifically the APOE4 allele. However, it has been known for a while that the risk due to the APOE4 allele differs considerably across populations, with Europeans having a greater risk from the APOE4 allele than Africans and African Americans.

“If you inherited your APOE4 allele from your African ancestor, you have a lower risk for Alzheimer disease than if you inherited your APOE4 allele from…

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