Regulating copper in the brain stops memory loss in a mouse model of Alzheimer’s

lab mouse
Credit: CC0 Public Domain

Alzheimer’s disease is characterized by the presence of amyloid plaques in the patient’s brain. These plaques sequester copper, and contain approximately five times as much as a healthy brain.

Two CNRS scientists from the Coordination Chemistry Laboratory recently developed, with their colleagues from the Guangdong University of Technology and Shenzhen University (China), a molecule that regulates the circulation of copper in the brain.

The molecule extracts the copper trapped in , and reintroduces it in the brain’s normal enzymatic circuit (which needs copper to function). Administered orally to an Alzheimer’s…

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