A comparison of machine learning methods for survival analysis of high-dimensional clinical data for dementia prediction

Participant cohorts

Sydney Memory and Ageing Study (MAS)

Subjects were selected from the Sydney Memory and Ageing Study (MAS), a longitudinal cohort study aimed at examining the characteristics and prevalence of mild cognitive impairment and dementia. MAS was initiated in 2005, randomly recruiting 1037 community-dwelling adults, aged 70–90 years at baseline, from the electoral roll of two federal government electoral areas in eastern Sydney, Australia. Full details of the study can be found14.

Ethics approval for the study was granted by the Human Research Ethics Committees of the University of New South Wales and the South Eastern Sydney and Illawarra Area Health Service. All participants and informants gave written informed consent. The MAS study and this work were carried out in accordance with the MAS Governance guidelines, which are based on relevant University of New South…

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