Novel technique spotlights neuronal uptake of amyloid beta in Alzheimer’s disease

Novel technique spotlights neuronal uptake of amyloid beta in Alzheimer's disease
Confocal images of cells with and without the cellular prion protein (labeled red), showing uptake of amyloid beta (labeled green) in cells with the prion protein (above) and no uptake in cells lacking the prion protein (below). (Magenta is membrane dye and blue is nuclear dye.) Credit: Graham Roseman, UCSC

One of the hallmarks of Alzheimer’s disease is the formation of amyloid plaques—sticky clumps of a protein called amyloid beta—that collect between neurons in the brain. Increasingly, however, attention has turned from these insoluble plaques to soluble forms of amyloid beta that can be taken up into neurons and are highly neurotoxic.

A new study by…

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