Brain regions with impaired blood flow have higher tau levels

Brain regions with impaired blood flow have higher tau levels
Brain regions with a negative correlation between blood flow and tau. Alzheimer’s disease and mild cognitive impairment on the left, cognitively normal on the right. Credit: Albrecht et al., JNeurosci 2020

In Alzheimer’s disease, impaired blood flow to brain regions coincides with tau protein buildup. This relationship strengthens as cognition declines, according to new research published in JNeurosci.

Vascular function declines and amyloid-β and accumulate as Alzheimer’s disease progresses, resulting in neuron death. Like the proverbial chicken and egg, it remains unclear if impaired causes or is caused by errant protein buildup,…

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