Few studies have investigated the frequency of APOE e4 alleles in the continuum of NC and AD in Asia7, although some similar studies in Western countries have been reported5,6. In the present study, an ordered trend in the frequency of the APOE e4 allele was observed: AD (30.8%), L-aMCI (24.0%), E-aMCI (15.1%), SMI (11.7%), and control (9.1%) groups, suggesting that there is an increasing trend in the frequency of APOE e4 alleles in the AD spectrum. Furthermore, APOE e4 carrier showed more rapid cognitive decline than APOE e4 non-carrier from SMI to L-aMCI while in AD, APOE e4 non-carrier showed more rapid cognitive decline than APOE e4 carrier. Therefore, our findings replicated that APOE e4 genotype is a prognostic factor of AD as well as important risk factor.
We investigated the distribution of APOE genotypes in AD, L-aMCI, E-aMCI, SMI, and control groups in Korea. Across all…
