With the advent of super-resolution microscopy, scientists can study close protein associations better than ever before. In the latest edition of eLife, the team of Wim Annaert (VIB-KU Leuven) combines state-of-the-art imaging techniques to investigate the distribution of γ-secretase, a protein complex associated with both Alzheimer’s disease and cancer.
γ-Secretase is a transmembrane enzyme complex consisting of four different protein subunits. It has received a lot of research attention because of its link to Alzheimer’s disease and cancer but because of a lack of resolution, it has for long been difficult to directly visualize protein associations within and between…
