Yeast protein could offer clues to how Alzheimer’s plaques form in the brain

Yeast protein could offer clues to how Alzheimer’s plaques form in the brain
MIT biologists found that the yeast protein Rim4 forms disordered clumps similar to the beta-amyloid plaques associated with Alzheimer’s disease, shown here. Credit: National Institute on Aging/NIH

Fibrous protein clumps known as amyloids are most often associated with diseases such as Alzheimer’s disease, where they form characteristic plaques in the brain.

Scientists first described amyloids about 150 years ago; they have since been tagged as key players in Parkinson’s disease, Huntington’s disease, and rheumatoid arthritis, as well as Alzheimer’s. However, recent findings suggest that this class of proteins may also have critical biological functions in .

In a study appearing in this…

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