Protein associated with ovarian cancer exacerbates neurodegeneration in Alzheimer’s

Protein associated with ovarian cancer exacerbates neurodegeneration in Alzheimer's
In the brain of mice with Alzheimer’s, areas near amyloid plaques (A) appear with fewer neural networks (B), dying neurons (C) and higher OCIAD1 (D). In cultured neuronal cells, the OCIAD1 proteins (E) appear in the mitochondria (F). Credit: Houston Methodist

Houston Methodist scientists identified a protein found in ovarian cancer that may contribute to declining brain function and Alzheimer’s disease, by combining computational methods and lab research.

“Our finding suggests another known protein may be coming into play here, which could help us identify a new therapeutic target one day,” said Stephen T.C. Wong, Ph.D., lead author and Associate Director of Bioinformatics and Biostatistics Cores at…

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