Spatial memory consolidation is preserved in APP/PS1 mice
To characterize the effect of APP/PS1 modification on spatial memory processing, APP/PS1 and wild-type littermate control (WT) mice were trained during 6 days to navigate in an 8-arm radial maze to learn the spatial position of three arms containing food rewards (Fig. 1a2). APP/PS1 mice performance remained consistently poorer than controls, showing ~5 errors per trial more during the course of learning (P < 0.05 on first 5 days, Wilcoxon rank-sum with Bonferroni correction) (Fig. 1b1). However, the slope of the learning curve was similar in both groups suggesting that APP/PS1 mice preserved some ability of learning the space.
APP-PS1 mice express impairment of working but not reference memory in 8-arm maze spatial memory test. (a1-2) Schematic representation of experimental paradigm. (a1) The animals were exposed…
