Flotillin is a novel diagnostic blood marker of Alzheimer’s disease

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dementianews
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Flotillin is a novel diagnostic blood marker of Alzheimer's disease
Flotillin in serum collected from patients with AD and non-AD cases was examined by western blot analysis. Intensity of flotillin bands was quantified using Image J. A, The representative results analyzed by western blot are shown. B, The quantitative analysis was performed and relative value of intensity of each band was normalized by the average value of flotillin in patients with non-AD as 1. Non-AD group, n=15; AD group, n=15. Data are mean ± S.E.M. Statistical analysis was performed by ANOVA. Credit: © Makoto Michikawa

Currently, best-characterized indicators for Alzheimer’s disease (AD) diagnosis are the decreased levels of amyloid β-protein 42 and increased levels of phosphorylated tau in cerebrospinal fluid (CSF). Positron emission tomography (PET) imaging with Pittsburgh compound B (PiB) is also used in AD diagnosis…

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