Fig. 2

Mean AD-like relevance maps for different subject groups, demonstrating the discriminative subregions that distinguish AD from NC subjects and characterizing the imaging patterns along the progression of AD dementia. Warmer color indicates severer brain degeneration and more relevant to the progression to AD, and cool color indicates rare brain degeneration and irrelevant to the progression to AD. The hippocampus panel shows mean hippocampal segmentation maps across subjects in different views (A: anterior, P: posterior, M: medial, L: lateral, S: superior, I: inferior). The mean maps have values in [0,1], indicating each voxel’s percentage for being located in the hippocampus across subjects whose brain images were registered to the Montreal Neurological Institute space. The segmentation maps serve as spatial references to the hippocampal locations for the AD relevance maps….