Amyloid fibrils play a crucial role in neurodegenerative illnesses. Scientists from Heinrich Heine University Düsseldorf (HHU) and Forschungszentrum Jülich have now been able to use cryo-electron microscopy (cryo-EM) to decode the spatial structure of the fibrils that are formed from PI3K SH3 domains—an important model system for research. Although the fibrils examined are not themselves connected with an illness, the findings made and methods developed could serve to understand diseases such as Alzheimer’s and Parkinson’s.
…
