Ethics statement
The research involving animals was authorized by the Italian Ministry of Health, Department of Veterinary Public Health, Nutrition and Food Safety, Directorate General of Animal Health and Veterinary Medicine, as required by Italian legislation (D. Lgs 26/2014, application of European Directive 2010/63/EU). All efforts were made to minimize the number of animals used and their suffering during the experimental procedures. All mouse experiments were carried out in accordance with guidelines prescribed by the Ethics Committee for the use of laboratory animals for research purposes at the University of Verona and by the Italian Ministry of Health.
Mice
The 3xTg-AD mice (MMRRC stock no. 34830-JAX) and wild-type control B6129SF2/J (stock no. 101045) were purchased from The Jackson Laboratory. The 3xTg-AD mouse expresses the human mutant APPswe and PS1M146V mutant alleles…
