Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and...
1.Kunkle, B. W. et al. Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat. Genet. 51, 414–430 (2019).CAS
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Prevention of Dementia by Intensive Vascular Care (PreDIVA): A Cluster-randomized Trial in Progress
Background and Purpose
Cardiovascular risk factors are associated with an increased risk of dementia. Treatment of hypertension and hypercholesterolemia is associated with a decrease in incident dementia. Whether interventions aimed at cardiovascular risk factors...
A Checklist for Radiology Departments Seeking to Purchase AI
Development of artificial intelligence (AI) has led to more widespread use in healthcare, including radiology. There is great hope for AI as a strong companion for radiologists to enhance accuracy,...
Signaling factor that sets time in the brain also required for normal memory in...
Society for Neuroscience. "Time-keeping brain protein influences memory: Signaling factor that sets time in the brain also required for normal memory in fruit flies." ScienceDaily. ScienceDaily, 26 October 2020. <www.sciencedaily.com/releases/2020/10/201026135742.htm>.
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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s...
Differential transcriptomic effects of TREM2 stimulation versus deletion in human iPSC-microgliaBecause preliminary data on TREM2 function suggests that AD-associated TREM2 mutations result in a partial loss of function19, we sought to mimic this effect...
Gene links short-term memory to unexpected brain area — ScienceDaily
A new study in mice identifies a gene that is critical for short-term memory but functions in a part of the brain not traditionally associated with memory.
The study, "A Thalamic Orphan Receptor Drives Variability...
Crocus-derived compounds alter the aggregation pathway of Alzheimer’s Disease: associated beta amyloid protein
Formation of Aβ oligomeric assemblies and fibrilsConsistent with previous results13,14,20, the ESI mass spectrum of Aβ1-40 shows primarily multiply charged ions of the monomer, ranging from +2 to +6 (Fig. 2b). Furthermore, weak signals corresponding...
Cognitive Behavioral Group Intervention for Alzheimer Caregivers
Long-term caregiving of patients with Alzheimer disease (AD) frequently induces a relevant distress enhanced by inadequate coping strategies. This study aimed to explore the impact of cognitive and behavioral therapy (CBT) group intervention on...
EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease
1.Dubois, B. et al. Advancing research diagnostic criteria for Alzheimer’s disease: The IWG-2 criteria. Lancet Neurol. 13, 614–629 (2014).PubMed
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Improving Access to Breast Cancer Care in the East Bay
Research has shown that better cancer survival outcomes derive from improvements in prevention, screening, treatment and follow-up care. Also critical is improving access to care, says the American Cancer Society....
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...