The relationship between the immune system and the progression of AD has recently been investigated12,13. However, the association between various Ig isotypes and subclasses in AD parenchyma has not been evaluated. By examining fresh-frozen frontal cortex (FCx) brain tissue from pathologically diagnosed AD (Braak and Braak stage III, V, and VI) and age-matched cognitively normal individuals (Normal), we demonstrated that the levels of Ig’s were significantly altered in AD subjects compared to Normal. Furthermore, the trends of these Ig’s with increasing Braak and Braak stages suggest a relationship with the pathological progression of AD.
Immunoglobulin M (IgM) is the first antibody isotype produced by B-cells in an immune response that provides short term protection by opsonizing antigens/pathogens30,31,32,33,34,35. B-cells in the dura region of the meninges, either locally…
