Understanding memory loss in Alzheimer’s disease

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dementianews
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Understanding memory loss in Alzheimer's disease
Fig. 1. Generation of NrxnCTF transgenic mice. A) Schematic drawings showing the proteolytic processing of Nrxns by metalloproteases and PS (left) and the HA-tagged NrxnCTF transgene used in this study (right). The regions recognized by the HA and the cyto-Nrxn antibodies are indicated. LNS, Laminin/Neurexin/Sex hormone binding-globulin domain; TM, transmembrane region. B) Representation showing the genetic approach for the expression of NrxnCTF in the forebrain. C) Expression of NrxnCTF in forebrain tissues of NrxnCTF mouse lines. NrxnCTF expression was analyzed in cortex, hippocampus and striatum by Western-blot experiments with HA and cyto-Neurexin antibodies, as indicated. Lysates from single transgenic CaMKIIα-tTA and TRE-NrxnCTF mouse lines were analyzed as additional controls. Credit: DOI:…

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