Exercise alters brain chemistry to protect aging synapses

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Credit: Unsplash/CC0 Public Domain

When elderly people stay active, their brains have more of a class of proteins that enhances the connections between neurons to maintain healthy cognition, a UC San Francisco study has found.

This protective impact was found even in people whose brains at autopsy were riddled with toxic proteins associated with Alzheimer’s and other neurodegenerative diseases.

“Our work is the first that uses human data to show that synaptic regulation is related to and may drive the beneficial cognitive outcomes we see,” said Kaitlin Casaletto, Ph.D., an assistant professor of neurology and lead author on the study,…

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