Sensitivity to painful external stimuli preserved in all phases of Alzheimer’s disease in mice

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dementianews
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Sensitivity to painful external stimuli preserved in all phases of Alzheimer's disease in mice
Figure 1. Schematic representation of the plantar test of thermal stimuli protocol used. Sensory-discriminative dimension of thermal withdrawal response in male and female 3xTg-AD and age-matched NTg mice with normal aging. (A) At low-20W and high-40W active intensity, infrared light stimuli were applied underneath the plantar surface of the mice’s hind paws (both right and left) and tail every 10 min. Paw (PWL) and tail (TWL) withdrawal latency were recorded for a sensory-discriminative dimension and the total number of defecations for an affective-emotional dimension. (B) Hind paw withdrawal responses at low-intensity 20-W (C) and high-intensity 40-W (D). Tail withdrawal at low-intensity 20-W (E) and high-intensity 40-W. Groups: NTg, non-transgenic mice (open bar); 3xTg-AD, transgenic mice (male “black,”…

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