Microscopic image of human locus coeruleus nerve cells, pseudo-coloured in blue, expressing the GABA-A alpha 3 receptor, pseudo-coloured in yellow. Note how the signal for the alpha 3 receptors almost completely cover the LC cells, indicating how important this protein is to controlling LC activity. The study found that Alzheimer’s pathology impairs the expression and function of this protein, thereby impairing LC function. Credit: University of Portsmouth
Neuroscientists at the University of Portsmouth, with collaborators in the UK and the U.S., have made a breakthrough in the study of Alzheimer’s which could inspire better treatments and earlier diagnosis.
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
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