Scientists discover mutations associated with early onset dementia

Scientists discover mutations associated with early onset dementia
Glial fibrillary acidic protein (GFAP) and Claudin-5 staining of an affected cell. Credit: Trinity College Dublin.

Scientists at Trinity College Dublin today announced a significant advance in our understanding of an early onset form of dementia that may also progress our understanding of conditions such as Alzheimer’s disease.

Adult onset Leukoencephalopathy with axonal Spheroids and Pigmented glia (ALSP) is an ultra-rare condition characterized by mutations in a gene called Colony stimulating factor-1 receptor (CSF1R). The condition manifests initially with psychiatric and in patients followed by a rapid progression of dementia in the third…

Read more…