Newly discovered mechanism can explain increased risk of dementia

Newly discovered mechanism can explain increased risk of dementia
Proton pump inhibitors’ effect on the enzyme that synthesizes the neurotransmitter acetylcholine. Credit: Taher Darreh-Shori

Millions of people around the world use proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report that the long-term use of these drugs could increase the risk of developing dementia. Their results are published in the journal Alzheimer’s & Dementia.

“We’ve been able to show that affect the synthesis of the neurotransmitter , which plays a significant part in conditions such as Alzheimer’s disease,” says Taher Darreh-Shori, senior researcher at the Department…

Read more…