3-D brain-like tissue model links Alzheimer’s disease with herpes

3D brain-like tissue model links Alzheimer's disease with herpes
Fluorescent immunostaining in which the red shows amyloid beta fibrils, the green indicates HSV-1-infected cells, and the blue indicates dead cells stained with DAPI. Credit: Dana Cairns, Tufts University

Engineers and scientists led by Tufts University used a three-dimensional (3-D) human tissue culture model mimicking the components and conditions in the brain to demonstrate a possible causal relationship between sporadic Alzheimer’s disease and herpes simplex virus I infection (HSV-1). Reported today in Science Advances, the model will allow for further studies into the causes and possible treatments of this devastating neurodegenerative condition.

After infecting neurons in the bioengineered brain…

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