Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

In this study, we used the SOMAscan assay to measure 4001 proteins in plasma in two groups of subjects from the EMIF-AD MBD study. Using machine learning, we identified a panel of 44 proteins that, along with age and APOE ε4, predicted measures of central amyloid with good performance in both the discovery group (AUC = 0.78) and the replication group…

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