Bacteria in the nose may increase risk of Alzheimer’s disease

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dementianews
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Bacteria in the nose may increase risk of Alzheimer's disease
Schematics illustrating the process for quantifying the amount of viable infectious C. pneumoniae present in various mouse tissues. (A) Mice were first intranasally inoculated with C. pneumoniae (i), some with epithelial injury and some without. Following either 24 h, 3 days or 7 days or 28 days post inoculation, selected tissues were collected and homogenized in tubes (ii). Homogenates were serially diluted onto HEp-2 cells and incubated (iii). Cells were fixed and immunolabelled for C. pneumoniae inclusions, which were counted and the number of inclusion-forming units (IFUs) per mL of homogenate was determined. Data were then compiled into organ (tissue) load graphs (see Fig. 2). (B) Microscopic image showing a sagittal tissue section of a mouse brain. Cell nuclei/DNA are shown in blue (DAPI stain). Key…

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