Novel risk loci and mechanistic insights into Alzheimer disease (AD) and Lewy body dementia (LBD) have emerged from two recent studies published in Nature Genetics. The findings take us a step further in our understanding of the biological basis of dementia in different diseases.
In AD, many genetic risk loci have been identified from several genome-wide association studies (GWASs). However, this genetic information is only the first step towards determining which genes contribute to AD risk and identifying the mechanisms behind these associations. In the first of the two new studies, Jeremy Schwartzentruber and colleagues set out to gain new insight into the gene variants that cause AD by combining data from previous…
