In this nationwide study, we found a significantly increased risk of newly diagnosed AD among patients with psoriasis compared to age- and sex-matched controls without psoriasis. This association was significantly stronger in middle-aged patients than in elderly patients (≥65 years) with psoriasis (HR: 1.30 vs. HR: 1.08). We also observed that those patients with psoriasis who were treated with systemic therapy had a lower risk of AD than that of controls without psoriasis.
Although the exact mechanism of AD has not been fully elucidated, increasing evidence has implied that neuroinflammation plays an important role in its development11,12,13. In AD, the activation of microglial cells, the key inflammatory cells in the brain, induces the release of proinflammatory mediators, resulting in neuronal damage14. In addition, IL-12/IL-23 signaling has been implicated in the development of…
