Could Calorie Restriction Mimetics Hold the Key?

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Older woman eating appleFor decades, researchers have studied eating patterns—what, when, and how much we eat—to see how they might help us avoid age-related diseases like heart disease, diabetes, and dementia. They are also interested in learning more about how different eating patterns might affect the health of our musculoskeletal system, which comprises the body’s muscles, bones, and connective tissue.

Of particular interest to researchers is calorie restriction, which involves reducing average daily caloric intake below what is typical or habitual without malnutrition or deprivation of essential nutrients. Calorie restriction can be also accomplished by not eating at all for a period of hours or days (known as “intermittent fasting”) or by eating less at some or all meals. Some studies in animals and humans have shown that calorie restriction can lead to improvements in…

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