Researchers looking to unlock the mysteries of Alzheimer’s disease have revealed new insights from old variants.
A gene called apolipoprotein E (APOE), long implicated in Alzheimer’s disease, has two variants that act differently among Caribbean Hispanics depending on the ancestral origin, according to a study published in Alzheimer’s and Dementia.
In this study, individuals with African-derived ancestry in their APOE gene had 39 percent lower odds of Alzheimer’s than individuals with European-derived APOE.
“It’s the same variant but behaving differently,” said lead author Elizabeth Blue, associate professor in the Division of Medical Genetics at the University of Washington…
