Humans
Human subject tissue was procured through the Oregon Alzheimer’s Disease Center (ADC) and OHSU Department of Pathology and affected subjects had established clinical and pathological diagnoses (Dementia with Lewy Bodies). Tissue use was approved by the IRB at OHSU and performed in accordance with relevant guidelines. Informed consent was obtained from all participants and/or their legal representatives.
Animals
Animals were housed by OHSU’s Department of Comparative Medicine in a light-dark cycle and temperature- and humidity-controlled vivarium and maintained under ad libitum food and water diet. All experiments were approved by the OHSU IACUC, all experiments were performed in accordance with the relevant guidelines and regulations, and every effort was made to minimize the number of animals used and their suffering.
Mouse model generation
Transgenic mouse lines
Utilizing the…
